Evaluating the efficacy of prototype antiseizure drugs using a preclinical pharmacokinetic approach
Evaluating the efficacy of prototype antiseizure drugs using a preclinical pharmacokinetic approach
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Cold Spring Harbor: Cold Spring Harbor Laboratory Press
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English
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Cold Spring Harbor: Cold Spring Harbor Laboratory Press
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Objective: Pharmacokinetics (PK) of a drug drive its exposure, efficacy, and tolerability. A thorough preclinical PK assessment of antiseizure medications (ASMs) is therefore essential to evaluate the clinical potential. We tested protection against evoked seizures of prototype ASMs in conjunction with analysis of plasma and brain PK as a proof-of-...
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Full title
Evaluating the efficacy of prototype antiseizure drugs using a preclinical pharmacokinetic approach
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TN_cdi_proquest_journals_2686429451
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_2686429451
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E-ISSN
2692-8205
DOI
10.1101/2022.07.07.499055
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https://www.proquest.com/docview/2686429451?pq-origsite=primo&accountid=13902
