Senescence in yeast is associated with chromosome XII cleavage rather than ribosomal DNA circle accu...
Senescence in yeast is associated with chromosome XII cleavage rather than ribosomal DNA circle accumulation
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Cold Spring Harbor: Cold Spring Harbor Laboratory Press
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English
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Cold Spring Harbor: Cold Spring Harbor Laboratory Press
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Contents
The massive accumulation of extrachromosomal ribosomal DNA circles (ERCs) in yeast mother cells has been long cited as the primary driver of replicative ageing. ERCs arise through ribosomal DNA (rDNA) recombination and a wealth of genetic data connects rDNA instability to shortened lifespan and other ageing pathologies. However, we understand littl...
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Full title
Senescence in yeast is associated with chromosome XII cleavage rather than ribosomal DNA circle accumulation
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TN_cdi_proquest_journals_2689387377
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_2689387377
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DOI
10.1101/2022.07.14.500009
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https://www.proquest.com/docview/2689387377?pq-origsite=primo&accountid=13902
