N-terminal acetylation shields proteins from degradation and promotes age-dependent motility and lon...
N-terminal acetylation shields proteins from degradation and promotes age-dependent motility and longevity
About this item
Full title
Author / Creator
Varland, Sylvia , Rui Duarte Silva , Kjosas, Ine , Faustino, Alexandra , Bogaert, Annelies , Billmann, Maximilian , Boukhatmi, Hadi , Kellen, Barbara , Costanzo, Michael , Drazic, Adrian , Osberg, Camilla , Chan, Katherine , Zhang, Xiang , Yan Tong, Amy Hin , Andreazza, Simonetta , Lee, Juliette J , Nedyalkova, Lyudmila , Usaj, Matej , Whitworth, Alexander J , Andrews, Brenda J , Moffat, Jason , Myers, Chad L , Gevaert, Kris , Boone, Charlie , Rui Goncalo Martinho and Arnesen, Thomas
Publisher
Cold Spring Harbor: Cold Spring Harbor Laboratory Press
Journal title
Language
English
Formats
Publication information
Publisher
Cold Spring Harbor: Cold Spring Harbor Laboratory Press
Subjects
More information
Scope and Contents
Contents
Most eukaryotic proteins are N-terminally acetylated, but the functional impact on a global scale has remained obscure. Using genome-wide CRISPR knockout screens in human cells, we reveal a strong genetic dependency between a major N-terminal acetyltransferase and specific ubiquitin ligases. Biochemical analyses uncover that both the ubiquitin liga...
Alternative Titles
Full title
N-terminal acetylation shields proteins from degradation and promotes age-dependent motility and longevity
Authors, Artists and Contributors
Author / Creator
Rui Duarte Silva
Kjosas, Ine
Faustino, Alexandra
Bogaert, Annelies
Billmann, Maximilian
Boukhatmi, Hadi
Kellen, Barbara
Costanzo, Michael
Drazic, Adrian
Osberg, Camilla
Chan, Katherine
Zhang, Xiang
Yan Tong, Amy Hin
Andreazza, Simonetta
Lee, Juliette J
Nedyalkova, Lyudmila
Usaj, Matej
Whitworth, Alexander J
Andrews, Brenda J
Moffat, Jason
Myers, Chad L
Gevaert, Kris
Boone, Charlie
Rui Goncalo Martinho
Arnesen, Thomas
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_proquest_journals_2709202327
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_2709202327
Other Identifiers
E-ISSN
2692-8205
DOI
10.1101/2022.09.01.505523
How to access this item
https://www.proquest.com/docview/2709202327?pq-origsite=primo&accountid=13902
