Formulating a TMEM176B blocker in nanoparticles uncouples its paradoxical roles in innate and adapti...
Formulating a TMEM176B blocker in nanoparticles uncouples its paradoxical roles in innate and adaptive antitumoral immunity
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Cold Spring Harbor: Cold Spring Harbor Laboratory Press
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English
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Cold Spring Harbor: Cold Spring Harbor Laboratory Press
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The immunoregulatory cation channel TMEM176B plays a dual role in tumor immunity. On one hand, TMEM176B promotes antigen cross-presentation to CD8+ T cells by regulating phagosomal pH in dendritic cells (DCs). On the other hand, TMEM176B inhibits NLRP3 inflammasome activation through ionic mechanisms in DCs, monocytes and macrophages. Moreover, the...
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Formulating a TMEM176B blocker in nanoparticles uncouples its paradoxical roles in innate and adaptive antitumoral immunity
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TN_cdi_proquest_journals_2709801903
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_2709801903
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E-ISSN
2692-8205
DOI
10.1101/2022.09.02.506404
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https://www.proquest.com/docview/2709801903?pq-origsite=primo&accountid=13902
