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Assessment of pre-clinical liver models based on their ability to predict the liver-tropism of AAV v...

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Assessment of pre-clinical liver models based on their ability to predict the liver-tropism of AAV v...

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_2719591647

Assessment of pre-clinical liver models based on their ability to predict the liver-tropism of AAV vectors

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Cold Spring Harbor: Cold Spring Harbor Laboratory Press

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Scope and Contents

Contents

The liver is a prime target for in vivo gene therapies using recombinant adeno-associated viral vectors (rAAV). Multiple clinical trials have been undertaken for this target in the past 15 years, however we are still to see market approval of the first liver-targeted AAV-based gene therapy. Inefficient expression of the therapeutic transgene, vecto...

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Full title

Assessment of pre-clinical liver models based on their ability to predict the liver-tropism of AAV vectors

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Record Identifier

TN_cdi_proquest_journals_2719591647

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_2719591647

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E-ISSN

2692-8205

DOI

10.1101/2022.09.28.510021

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