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RNAi-mediated rheostat for dynamic control of AAV-delivered transgenes

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RNAi-mediated rheostat for dynamic control of AAV-delivered transgenes

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_2719936935

RNAi-mediated rheostat for dynamic control of AAV-delivered transgenes

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Publication information

Publisher

Cold Spring Harbor: Cold Spring Harbor Laboratory Press

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Scope and Contents

Contents

Adeno-associated virus (AAV)-based gene therapy could be facilitated by the development of molecular switches to control the magnitude and timing of expression of therapeutic transgenes. RNA interference (RNAi)-based approaches hold unique potential as a clinically proven modality to pharmacologically regulate AAV gene dosage in a sequence-specific...

Alternative Titles

Full title

RNAi-mediated rheostat for dynamic control of AAV-delivered transgenes

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Record Identifier

TN_cdi_proquest_journals_2719936935

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_2719936935

Other Identifiers

ISSN

2692-8205

E-ISSN

2692-8205

DOI

10.1101/2022.09.30.510386

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