A reversible SRC-relayed COX2-inflammatory program drives therapeutic resistance in BRAF(V600E) colo...
A reversible SRC-relayed COX2-inflammatory program drives therapeutic resistance in BRAF(V600E) colorectal tumors
About this item
Full title
Author / Creator
Ruiz-Saenz, Ana , Atreya, Chloe E , Wang, Changjun , Pan, Bo , Dreyer, Courtney A , Diede Brunen , Prahallad, Anirudh , Munoz, Denise P , Ramms, Dana J , Burghi, Valeria , Spassov, Danislav S , Fewings, Eleanor , Hwang, Yeonjoo C , Cowdrey, Cynthia , Moelders, Christina , Schwarzer, Cecilia , Wolf, Denise M , Hann, Byron , Vandenberg, Scott R , Shokat, Kevan , Moasser, Mark M , Bernards, Rene , J Silvio Gutkind , Van't Veer, Laura J and Coppe, Jean-Philippe
Publisher
Cold Spring Harbor: Cold Spring Harbor Laboratory Press
Journal title
Language
English
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Publication information
Publisher
Cold Spring Harbor: Cold Spring Harbor Laboratory Press
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More information
Scope and Contents
Contents
BRAF(V600E) mutation confers a poor prognosis in metastatic colorectal cancer (CRC) despite combinatorial targeted therapies based on the latest understanding of signaling circuitry. To identify parallel resistance mechanisms induced by BRAF/MEK/EGFR co-targeting, we used a high throughput kinase activity mapping platform. We found that SRC kinases...
Alternative Titles
Full title
A reversible SRC-relayed COX2-inflammatory program drives therapeutic resistance in BRAF(V600E) colorectal tumors
Authors, Artists and Contributors
Author / Creator
Atreya, Chloe E
Wang, Changjun
Pan, Bo
Dreyer, Courtney A
Diede Brunen
Prahallad, Anirudh
Munoz, Denise P
Ramms, Dana J
Burghi, Valeria
Spassov, Danislav S
Fewings, Eleanor
Hwang, Yeonjoo C
Cowdrey, Cynthia
Moelders, Christina
Schwarzer, Cecilia
Wolf, Denise M
Hann, Byron
Vandenberg, Scott R
Shokat, Kevan
Moasser, Mark M
Bernards, Rene
J Silvio Gutkind
Van't Veer, Laura J
Coppe, Jean-Philippe
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_proquest_journals_2727082637
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_2727082637
Other Identifiers
DOI
10.1101/2022.10.20.512885
How to access this item
https://www.proquest.com/docview/2727082637?pq-origsite=primo&accountid=13902
