Topo II inhibition and DNA intercalation by new phthalazine-based derivatives as potent anticancer a...
Topo II inhibition and DNA intercalation by new phthalazine-based derivatives as potent anticancer agents: design, synthesis, anti-proliferative, docking, and in vivo studies
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Publisher
England: Taylor & Francis
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Language
English
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Publisher
England: Taylor & Francis
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Contents
This research presents the design and synthesis of a novel series of phthalazine derivatives as Topo II inhibitors, DNA intercalators, and cytotoxic agents. In vitro testing of the new compounds against HepG-2, MCF-7, and HCT-116 cell lines confirmed their potent cytotoxic activity with low IC
50
values. Topo II inhibition and DNA intercalati...
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Full title
Topo II inhibition and DNA intercalation by new phthalazine-based derivatives as potent anticancer agents: design, synthesis, anti-proliferative, docking, and in vivo studies
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TN_cdi_proquest_journals_2727916002
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_2727916002
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ISSN
1475-6366
E-ISSN
1475-6374
DOI
10.1080/14756366.2021.2007905
