Induced Degradation of Lineage-specific Oncoproteins Drives the Selective PARP1 Inhibitor Toxicity i...
Induced Degradation of Lineage-specific Oncoproteins Drives the Selective PARP1 Inhibitor Toxicity in Small Cell Lung Cancer
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Cold Spring Harbor: Cold Spring Harbor Laboratory Press
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English
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Cold Spring Harbor: Cold Spring Harbor Laboratory Press
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Contents
A subset of small cell lung cancer (SCLC) shows clinically relevant response to PARP1 inhibitors (PARPi). However, BRCA1/2 mutations are not commonly found in SCLC, and the underlying mechanism(s) of PARPi sensitivity in SCLC is poorly understood. We performed quantitative proteomic analyses and identified proteomic changes that signify PARPi respo...
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Full title
Induced Degradation of Lineage-specific Oncoproteins Drives the Selective PARP1 Inhibitor Toxicity in Small Cell Lung Cancer
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TN_cdi_proquest_journals_2731607028
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_2731607028
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E-ISSN
2692-8205
DOI
10.1101/2022.11.02.514072
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https://www.proquest.com/docview/2731607028?pq-origsite=primo&accountid=13902
