CpG dinucleotide enrichment in the influenza A virus genome as a live attenuated vaccine development...
CpG dinucleotide enrichment in the influenza A virus genome as a live attenuated vaccine development strategy
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Cold Spring Harbor: Cold Spring Harbor Laboratory Press
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English
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Cold Spring Harbor: Cold Spring Harbor Laboratory Press
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Synonymous recoding of RNA virus genomes is a promising approach for generating attenuated viruses to use as vaccines. Problematically, recoding typically hinders virus growth, but this may be rectified using CpG dinucleotide enrichment. CpGs are recognised by cellular zinc-finger antiviral protein (ZAP), and so in principle, removing ZAP sensing f...
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CpG dinucleotide enrichment in the influenza A virus genome as a live attenuated vaccine development strategy
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TN_cdi_proquest_journals_2731607657
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_2731607657
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E-ISSN
2692-8205
DOI
10.1101/2022.04.29.490024
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https://www.proquest.com/docview/2731607657?pq-origsite=primo&accountid=13902
