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Fluorescein-based sensors to purify human α-cells for functional and transcriptomic analyses

Fluorescein-based sensors to purify human α-cells for functional and transcriptomic analyses

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_2740677547

Fluorescein-based sensors to purify human α-cells for functional and transcriptomic analyses

About this item

Full title

Fluorescein-based sensors to purify human α-cells for functional and transcriptomic analyses

Publisher

Cold Spring Harbor: Cold Spring Harbor Laboratory Press

Journal title

bioRxiv, 2022-11

Language

English

Formats

Publication information

Publisher

Cold Spring Harbor: Cold Spring Harbor Laboratory Press

More information

Scope and Contents

Contents

Pancreatic α-cells secrete glucagon, an insulin counter-regulatory peptide hormone critical for the maintenance of glucose homeostasis. Investigation of the function of human α-cells remains a challenge due to the lack of cost-effective purification methods to isolate high-quality α-cells from islets. Here, we use the reaction-based probe diacetyla...

Alternative Titles

Full title

Fluorescein-based sensors to purify human α-cells for functional and transcriptomic analyses

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_proquest_journals_2740677547

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_2740677547

Other Identifiers

E-ISSN

2692-8205

DOI

10.1101/2022.11.27.518097