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An Autoimmune Transcriptional Circuit Driving Foxp3+ Regulatory T cell Dysfunction

An Autoimmune Transcriptional Circuit Driving Foxp3+ Regulatory T cell Dysfunction

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_2745489636

An Autoimmune Transcriptional Circuit Driving Foxp3+ Regulatory T cell Dysfunction

About this item

Full title

An Autoimmune Transcriptional Circuit Driving Foxp3+ Regulatory T cell Dysfunction

Publisher

Cold Spring Harbor: Cold Spring Harbor Laboratory Press

Journal title

bioRxiv, 2022-12

Language

English

Formats

Publication information

Publisher

Cold Spring Harbor: Cold Spring Harbor Laboratory Press

More information

Scope and Contents

Contents

Autoimmune diseases, among the most common disorders of young adults, are mediated by genetic and environmental factors. While CD4+Foxp3+ regulatory T cells (Tregs) play a central role in preventing autoimmunity, the molecular mechanism underlying their dysfunction is unknown. Here, we performed comprehensive transcriptomic and epigenomic profiling...

Alternative Titles

Full title

An Autoimmune Transcriptional Circuit Driving Foxp3+ Regulatory T cell Dysfunction

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_proquest_journals_2745489636

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_2745489636

Other Identifiers

E-ISSN

2692-8205

DOI

10.1101/2022.12.02.518871