Structural basis for modulation of Kv4 K+ channels by auxiliary KChIP subunits
Structural basis for modulation of Kv4 K+ channels by auxiliary KChIP subunits
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Author / Creator
Wang, Huayi , Yan, Yan , Liu, Qun , Huang, Yanhua , Shen, Yue , Chen, Linjie , Chen, Yi , Yang, Qiuyue , Hao, Quan , Wang, KeWei and Chai, Jijie
Publisher
New York: Nature Publishing Group US
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Language
English
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Publisher
New York: Nature Publishing Group US
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Contents
KChIPs coassemble with pore-forming Kv4 α subunits to form a native complex in the brain and heart and regulate the expression and gating properties of Kv4 K
+
channels, but the mechanisms underlying these processes are unknown. Here we report a co-crystal structure of the complex of human Kv4.3 N-terminus and KChIP1 at a 3.2-Å resolution. Th...
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Full title
Structural basis for modulation of Kv4 K+ channels by auxiliary KChIP subunits
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TN_cdi_proquest_journals_274623776
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_274623776
Other Identifiers
ISSN
1097-6256
E-ISSN
1546-1726
DOI
10.1038/nn1822
