Chemo-Enzymatic Synthesis of Enantiopure β-Antagonist (S)-Betaxolol
Chemo-Enzymatic Synthesis of Enantiopure β-Antagonist (S)-Betaxolol
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Basel: MDPI AG
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Language
English
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Basel: MDPI AG
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Contents
The β-blocker (S)-betaxolol has been synthesized in 99% enantiomeric excess (ee) from the commercially available precursor 4-(2-hydroxyethyl)phenol. The racemic chlorohydrin 1-chloro-3-(4-(2-(cyclopropylmethoxy)ethyl)phenoxy)propan-2-ol was esterified with vinyl acetate catalyzed by lipase B from Candida antarctica, which gave the R-chlorhydrin (R)...
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Chemo-Enzymatic Synthesis of Enantiopure β-Antagonist (S)-Betaxolol
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TN_cdi_proquest_journals_2756675980
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_2756675980
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ISSN
2073-4344
E-ISSN
2073-4344
DOI
10.3390/catal12121645
