C/EBPβ/AEP is age-dependently activated in Parkinson’s disease and mediates α-synuclein in the gut a...
C/EBPβ/AEP is age-dependently activated in Parkinson’s disease and mediates α-synuclein in the gut and brain
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Author / Creator
Wang, Hualong , Chen, Guiqin , Ahn, Eun Hee , Xia, Yiyuan , Kang, Seong Su , Liu, Xia , Liu, Chang , Han, Ming-Hu , Chen, Shengdi and Ye, Keqiang
Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
Parkinson’s disease (PD) is the most common neurodegenerative motor disorder, and its pathologic hallmarks include extensive dopaminergic neuronal degeneration in the Substantia nigra associated with Lewy bodies, predominantly consisting of phosphorylated and truncated α-Synuclein (α-Syn). Asparagine endopeptidase (AEP) cleaves human α-Syn at N103...
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Full title
C/EBPβ/AEP is age-dependently activated in Parkinson’s disease and mediates α-synuclein in the gut and brain
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TN_cdi_proquest_journals_2761457150
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_2761457150
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ISSN
2373-8057
E-ISSN
2373-8057
DOI
10.1038/s41531-022-00430-8
