Prdm16 mutation determines sex-specific cardiac metabolism and identifies two novel cardiac metaboli...
Prdm16 mutation determines sex-specific cardiac metabolism and identifies two novel cardiac metabolic regulators
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Author / Creator
Kuhnisch, Jirko , Theisen, Simon , Dartsch, Josephine , Fritsche-Guenther, Raphaela , Kirchner, Marieluise , Obermayer, Benedikt , Bauer, Anna , Anne-Karin Kahlert , Rothe, Michael , Beule, Dieter , Heuser, Arnd , Mertins, Philipp , Kirwan, Jennifer A , Berndt, Nikolaus , Macrae, Calum A , Hubner, Norbert and Klaassen, Sabine
Publisher
Cold Spring Harbor: Cold Spring Harbor Laboratory Press
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English
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Cold Spring Harbor: Cold Spring Harbor Laboratory Press
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Background: Mutation of the PRDM16 gene has been associated with human cardiomyopathy. The PRDM16 protein is a transcriptional regulator affecting cardiac development via Tbx5 and Hand1 regulating myocardial structure. Biallelic Prdm16 inactivation induces severe cardiac dysfunction with postnatal lethality and hypertrophy in mice. Early pathologic...
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Prdm16 mutation determines sex-specific cardiac metabolism and identifies two novel cardiac metabolic regulators
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TN_cdi_proquest_journals_2763157332
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_2763157332
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E-ISSN
2692-8205
DOI
10.1101/2023.01.10.523243
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https://www.proquest.com/docview/2763157332?pq-origsite=primo&accountid=13902
