Creation of Philadelphia chromosome by CRISPR/Cas9-mediated double cleavages on BCR and ABL1 genes a...
Creation of Philadelphia chromosome by CRISPR/Cas9-mediated double cleavages on BCR and ABL1 genes as a model for initial event in leukemogenesis
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New York: Nature Publishing Group US
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Language
English
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New York: Nature Publishing Group US
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Contents
The Philadelphia (Ph) chromosome was the first translocation identified in leukemia. It is supposed to be generated by aberrant ligation between two DNA double-strand breaks (DSBs) at the
BCR
gene located on chromosome 9q34 and the
ABL1
gene located on chromosome 22q11. Thus, mimicking the initiation process of translocation, we induced...
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Full title
Creation of Philadelphia chromosome by CRISPR/Cas9-mediated double cleavages on BCR and ABL1 genes as a model for initial event in leukemogenesis
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TN_cdi_proquest_journals_2765887740
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_2765887740
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ISSN
0929-1903,1476-5500
E-ISSN
1476-5500
DOI
10.1038/s41417-022-00522-w
