USP8 inhibition promotes Parkin-independent mitophagy in the Drosophila brain and in human neurons
USP8 inhibition promotes Parkin-independent mitophagy in the Drosophila brain and in human neurons
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Cold Spring Harbor: Cold Spring Harbor Laboratory Press
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English
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Cold Spring Harbor: Cold Spring Harbor Laboratory Press
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Stress-induced mitophagy, a tightly regulated process that targets dysfunctional mitochondria for autophagy-dependent degradation, mainly relays on two proteins, PINK1 and Parkin, which genes are mutated in some forms of familiar Parkinson Disease (PD). Upon mitochondrial damage, the protein kinase PINK1 accumulates on the organelle surface where i...
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USP8 inhibition promotes Parkin-independent mitophagy in the Drosophila brain and in human neurons
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TN_cdi_proquest_journals_2771172154
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_2771172154
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E-ISSN
2692-8205
DOI
10.1101/2023.01.30.526170
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https://www.proquest.com/docview/2771172154?pq-origsite=primo&accountid=13902
