STAT3 protects HSCs from intrinsic interferon signaling and loss of long-term blood-forming activity
STAT3 protects HSCs from intrinsic interferon signaling and loss of long-term blood-forming activity
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Author / Creator
Patel, Bhakti , Zhou, Yifan , Babcock, Rachel L , Ma, Feiyang , Zal, Malgorzata A , Kumar, Dhiraj , Medik, Yusra B , Kahn, Laura M , Pineda, Josué E , Park, Elizabeth M , Tang, Ximing , Raso, Maria Gabriela , Zal, Tomasz , Clise-Dwyer, Karen , Giancotti, Filippo G , Colla, Simona and Watowich, Stephanie S
Publisher
United States: Cold Spring Harbor Laboratory Press
Journal title
Language
English
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Publisher
United States: Cold Spring Harbor Laboratory Press
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Scope and Contents
Contents
STAT3 function in hematopoietic stem and progenitor cells (HSPCs) has been difficult to discern as
deficiency in the hematopoietic system induces systemic inflammation, which can impact HSPC activity. To address this, we established mixed bone marrow (BM) chimeric mice with CreER-mediated
deletion in 20% of the hematopoietic compartment.
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Alternative Titles
Full title
STAT3 protects HSCs from intrinsic interferon signaling and loss of long-term blood-forming activity
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Record Identifier
TN_cdi_proquest_journals_2775330435
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_2775330435
Other Identifiers
ISSN
2692-8205
E-ISSN
2692-8205
DOI
10.1101/2023.02.10.528069
