Pharmacometric model of agalsidase–migalastat interaction in human: a novel mechanistic model of dru...
Pharmacometric model of agalsidase–migalastat interaction in human: a novel mechanistic model of drug-drug interaction between a therapeutic protein and a small molecule
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Author / Creator
Bach, Thanh , Wu, Nan and An, Guohua
Publisher
New York: Springer US
Journal title
Language
English
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Publisher
New York: Springer US
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Scope and Contents
Contents
Recently, a new mechanism of drug–drug interaction (DDI) was reported between agalsidase, a therapeutic protein, and migalastat, a small molecule, both of which are treatment options of Fabry disease. Migalastat is a pharmacological chaperone that stabilizes the native form of both endogenous and exogenous agalsidase. In Fabry patients co-administr...
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Full title
Pharmacometric model of agalsidase–migalastat interaction in human: a novel mechanistic model of drug-drug interaction between a therapeutic protein and a small molecule
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Record Identifier
TN_cdi_proquest_journals_2777522724
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_2777522724
Other Identifiers
ISSN
1567-567X
E-ISSN
1573-8744
DOI
10.1007/s10928-022-09830-y
