Biophysical characterization and modeling of SCN1A gain-of-function predicts interneuron hyperexcita...
Biophysical characterization and modeling of SCN1A gain-of-function predicts interneuron hyperexcitability and a predisposition to network instability through homeostatic plasticity
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Cold Spring Harbor: Cold Spring Harbor Laboratory Press
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English
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Cold Spring Harbor: Cold Spring Harbor Laboratory Press
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SCN1A gain-of-function variants are associated with early onset developmental and epileptic encephalopathies (DEEs) that possess distinct clinical features compared to Dravet syndrome caused by SCN1A loss-of-function. However, it is unclear how SCN1A gain-of-function may predispose to cortical hyper-excitability and seizures. Here, we first report...
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Full title
Biophysical characterization and modeling of SCN1A gain-of-function predicts interneuron hyperexcitability and a predisposition to network instability through homeostatic plasticity
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TN_cdi_proquest_journals_2778471134
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_2778471134
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E-ISSN
2692-8205
DOI
10.1101/2023.02.20.529310
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https://www.proquest.com/docview/2778471134?pq-origsite=primo&accountid=13902
