Rab12 regulates LRRK2 activity by promoting its localization to lysosomes
Rab12 regulates LRRK2 activity by promoting its localization to lysosomes
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Cold Spring Harbor: Cold Spring Harbor Laboratory Press
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English
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Cold Spring Harbor: Cold Spring Harbor Laboratory Press
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Leucine-rich repeat kinase 2 (LRRK2) variants associated with Parkinson's disease (PD) and Crohn's disease lead to increased phosphorylation of its Rab substrates. While it has been recently shown that perturbations in cellular homeostasis including lysosomal damage and stress can increase LRRK2 activity and localization to lysosomes, the molecular...
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Full title
Rab12 regulates LRRK2 activity by promoting its localization to lysosomes
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TN_cdi_proquest_journals_2778756635
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_2778756635
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E-ISSN
2692-8205
DOI
10.1101/2023.02.21.529466
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https://www.proquest.com/docview/2778756635?pq-origsite=primo&accountid=13902
