Aberrant phase separation is a common killing strategy of positively charged peptides in biology and...
Aberrant phase separation is a common killing strategy of positively charged peptides in biology and human disease
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Author / Creator
Boeynaems, Steven , Ma, X Rosa , Yeong, Vivian , Ginell, Garrett M , Chen, Jian-Hua , Blum, Jacob A , Nakayama, Lisa , Sanyal, Anushka , Briner, Adam , Haver, Delphi Van , Pauwels, Jarne , Ekman, Axel , Schmidt, H Broder , Sundararajan, Kousik , Porta, Lucas , Lasker, Keren , Larabell, Carolyn , Hayashi, Mirian A F , Kundaje, Anshul , Impens, Francis , Obermeyer, Allie , Holehouse, Alex S and Gitler, Aaron D
Publisher
United States: Cold Spring Harbor Laboratory Press
Journal title
Language
English
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Publication information
Publisher
United States: Cold Spring Harbor Laboratory Press
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Scope and Contents
Contents
Positively charged repeat peptides are emerging as key players in neurodegenerative diseases. These peptides can perturb diverse cellular pathways but a unifying framework for how such promiscuous toxicity arises has remained elusive. We used mass-spectrometry-based proteomics to define the protein targets of these neurotoxic peptides and found tha...
Alternative Titles
Full title
Aberrant phase separation is a common killing strategy of positively charged peptides in biology and human disease
Authors, Artists and Contributors
Author / Creator
Ma, X Rosa
Yeong, Vivian
Ginell, Garrett M
Chen, Jian-Hua
Blum, Jacob A
Nakayama, Lisa
Sanyal, Anushka
Briner, Adam
Haver, Delphi Van
Pauwels, Jarne
Ekman, Axel
Schmidt, H Broder
Sundararajan, Kousik
Porta, Lucas
Lasker, Keren
Larabell, Carolyn
Hayashi, Mirian A F
Kundaje, Anshul
Impens, Francis
Obermeyer, Allie
Holehouse, Alex S
Gitler, Aaron D
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_proquest_journals_2784992805
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_2784992805
Other Identifiers
ISSN
2692-8205
E-ISSN
2692-8205
DOI
10.1101/2023.03.09.531820
