Loss of MC1R signaling implicates TBX3 in pheomelanogenesis and melanoma predisposition
Loss of MC1R signaling implicates TBX3 in pheomelanogenesis and melanoma predisposition
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Cold Spring Harbor: Cold Spring Harbor Laboratory Press
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English
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Cold Spring Harbor: Cold Spring Harbor Laboratory Press
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The human Red Hair Color (RHC) trait is caused by increased pheomelanin (red-yellow) and reduced eumelanin (black-brown) pigment in skin and hair due to diminished melanocortin 1 receptor (MC1R) function. In addition, individuals harboring the RHC trait are predisposed to melanoma development. While MC1R variants have been established as causative...
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Full title
Loss of MC1R signaling implicates TBX3 in pheomelanogenesis and melanoma predisposition
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TN_cdi_proquest_journals_2785473610
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_2785473610
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E-ISSN
2692-8205
DOI
10.1101/2023.03.10.532018
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https://www.proquest.com/docview/2785473610?pq-origsite=primo&accountid=13902
