Convenient access to β-substituted cysteines and β- and γ-mercapto prolines
Convenient access to β-substituted cysteines and β- and γ-mercapto prolines
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Ottawa: Canadian Science Publishing NRC Research Press
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Language
English
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Publisher
Ottawa: Canadian Science Publishing NRC Research Press
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Contents
Herein we describe a convenient method for the synthesis of the β-substituted Cys analogs 1a, b and trans-β-mercapto proline 1c, from their corresponding α,β-unsaturated-α-amino esters using p-methoxybenzyl mercaptan as the sulfur source. The intermediate β-thioethers are stable toward chromatographic purification, and after global deprotection the...
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Full title
Convenient access to β-substituted cysteines and β- and γ-mercapto prolines
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TN_cdi_proquest_journals_2807854828
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_2807854828
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ISSN
0008-4042
E-ISSN
1480-3291
DOI
10.1139/cjc-2022-0161