SRSF2-P95H decreases JAK/STAT signaling in hematopoietic cells and delays myelofibrosis development...
SRSF2-P95H decreases JAK/STAT signaling in hematopoietic cells and delays myelofibrosis development in mice
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Author / Creator
Willekens, Christophe , Laplane, Lucie , Dagher, Tracy , Benlabiod, Camelia , Papadopoulos, Nicolas , Lacout, Catherine , Rameau, Philippe , Catelain, Cyril , Alfaro, Alexia , Edmond, Valérie , Signolle, Nicolas , Marchand, Valentine , Droin, Nathalie , Hoogenboezem, Remco , Schneider, Rebekka K. , Penson, Alex , Abdel-Wahab, Omar , Giraudier, Stephane , Pasquier, Florence , Marty, Caroline , Plo, Isabelle , Villeval, Jean-Luc , Constantinescu, Stefan N. , Porteu, Françoise , Vainchenker, William and Solary, Eric
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
Heterozygous mutation targeting proline 95 in Serine/Arginine-rich Splicing Factor 2 (SRSF2) is associated with V617F mutation in Janus Activated Kinase 2 (JAK2) in some myeloproliferative neoplasms (MPNs), most commonly primary myelofibrosis. To explore the interaction of
Srsf2
P95H
with
Jak2
V617F
, we generated Cre-inducible kn...
Alternative Titles
Full title
SRSF2-P95H decreases JAK/STAT signaling in hematopoietic cells and delays myelofibrosis development in mice
Authors, Artists and Contributors
Author / Creator
Laplane, Lucie
Dagher, Tracy
Benlabiod, Camelia
Papadopoulos, Nicolas
Lacout, Catherine
Rameau, Philippe
Catelain, Cyril
Alfaro, Alexia
Edmond, Valérie
Signolle, Nicolas
Marchand, Valentine
Droin, Nathalie
Hoogenboezem, Remco
Schneider, Rebekka K.
Penson, Alex
Abdel-Wahab, Omar
Giraudier, Stephane
Pasquier, Florence
Marty, Caroline
Plo, Isabelle
Villeval, Jean-Luc
Constantinescu, Stefan N.
Porteu, Françoise
Vainchenker, William
Solary, Eric
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_proquest_journals_2822902724
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_2822902724
Other Identifiers
ISSN
0887-6924,1476-5551
E-ISSN
1476-5551
DOI
10.1038/s41375-023-01878-0
