854 HPK1 inhibition relieves suppression downstream of TCR activation to drive enhanced cytokine pro...
854 HPK1 inhibition relieves suppression downstream of TCR activation to drive enhanced cytokine production and antigen-specific killing, an effect that is further enhanced by immune checkpoint blockade
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Author / Creator
Singh, Rajesh , Patel, Bindi , Rayaji, Rameshwari , Marubayashi, Sachie , Cho, Sean , Garrido-Shaqfeh, Stefan , Kulusich, Joseph , Meleza, Cesar , Tibrewal, Nidhi , Joice, Thomas , Nareddy, Pradeep , Sharif, Ehesan , Zhao, Sharon , Green, Dave , Leleti, Manmohan , Powers, Jay , Walters, Matt and DiRenzo, Daniel
Publisher
London: BMJ Publishing Group LTD
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English
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Publisher
London: BMJ Publishing Group LTD
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Contents
BackgroundT cell activation is critical in the initiation and potentiation of anti-tumor immune responses. Hematopoietic Progenitor Kinase 1 (HPK1) is a member of the MAP4K family whose activity restrains T cell activation through phosphorylation of SLP-76 (pSLP-76) at Serine 376, leading to disassembly of the TCR complex. Mouse genetic deletion an...
Alternative Titles
Full title
854 HPK1 inhibition relieves suppression downstream of TCR activation to drive enhanced cytokine production and antigen-specific killing, an effect that is further enhanced by immune checkpoint blockade
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Record Identifier
TN_cdi_proquest_journals_2840756543
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_2840756543
Other Identifiers
E-ISSN
2051-1426
DOI
10.1136/jitc-2022-SITC2022.0854
