Discovery of a novel 1,3,4-oxadiazol-2-one-based NLRP3 inhibitor as a pharmacological agent to mitig...
Discovery of a novel 1,3,4-oxadiazol-2-one-based NLRP3 inhibitor as a pharmacological agent to mitigate cardiac and metabolic complications in an experimental model of diet-induced metaflammation
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Author / Creator
Gastaldi, Simone , Rocca, Carmine , Gianquinto, Eleonora , Granieri, Maria Concetta , Boscaro, Valentina , Blua, Federica , Rolando, Barbara , Marini, Elisabetta , Gallicchio, Margherita , De Bartolo, Anna , Romeo, Naomi , Mazza, Rosa , Fedele, Francesco , Pagliaro, Pasquale , Penna, Claudia , Spyrakis, Francesca , Bertinaria, Massimo and Angelone, Tommaso
Publisher
Ithaca: Cornell University Library, arXiv.org
Journal title
Language
English
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Publisher
Ithaca: Cornell University Library, arXiv.org
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Scope and Contents
Contents
Inspired by the recent advancements in understanding the binding mode of sulfonylurea-based NLRP3 inhibitors to the NLRP3 sensor protein, we developed new NLRP3 inhibitors by replacing the central sulfonylurea moiety with different heterocycles. Computational studies evidenced that some of the designed compounds were able to maintain important inte...
Alternative Titles
Full title
Discovery of a novel 1,3,4-oxadiazol-2-one-based NLRP3 inhibitor as a pharmacological agent to mitigate cardiac and metabolic complications in an experimental model of diet-induced metaflammation
Authors, Artists and Contributors
Author / Creator
Rocca, Carmine
Gianquinto, Eleonora
Granieri, Maria Concetta
Boscaro, Valentina
Blua, Federica
Rolando, Barbara
Marini, Elisabetta
Gallicchio, Margherita
De Bartolo, Anna
Romeo, Naomi
Mazza, Rosa
Fedele, Francesco
Pagliaro, Pasquale
Penna, Claudia
Spyrakis, Francesca
Bertinaria, Massimo
Angelone, Tommaso
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Primary Identifiers
Record Identifier
TN_cdi_proquest_journals_2865942156
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_2865942156
Other Identifiers
E-ISSN
2331-8422
