SPAG7 deletion causes intrauterine growth restriction, resulting in adulthood obesity and metabolic...
SPAG7 deletion causes intrauterine growth restriction, resulting in adulthood obesity and metabolic dysfunction
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Author / Creator
Flaherty, Stephen E , Bezy, Olivier , Paulhus, Brianna Lacarubba , Song, Loujin , Piper, Mary , Pang, Jincheng , Park, Yoson , Asano, Shoh , Yu-Chin, Lien , Griffin, John D , Robertson, Andrew , Opsahl, Alan , Shanthappa, Dinesh Hirenallur , Ahn, Youngwook , Pashos, Evanthia , Simmons, Rebecca A , Birnbaum, Morris J and Wu, Zhidan
Publisher
Cold Spring Harbor: Cold Spring Harbor Laboratory Press
Journal title
Language
English
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Publisher
Cold Spring Harbor: Cold Spring Harbor Laboratory Press
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Contents
From a forward mutagenetic screen to discover mutations associated with obesity, we identified mutations in the spag7 gene linked to metabolic dysfunction in mice. Here we show that SPAG7 KO mice are born smaller and develop obesity and glucose intolerance in adulthood. This obesity does not stem from hyperphagia, but a decrease in energy expenditu...
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Full title
SPAG7 deletion causes intrauterine growth restriction, resulting in adulthood obesity and metabolic dysfunction
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TN_cdi_proquest_journals_2886741082
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_2886741082
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E-ISSN
2692-8205
DOI
10.1101/2023.09.05.555087
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https://www.proquest.com/docview/2886741082?pq-origsite=primo&accountid=13902
