Introduction of the T315I gatekeeper mutation of BCR/ABL1 into a Philadelphia chromosome-positive ly...
Introduction of the T315I gatekeeper mutation of BCR/ABL1 into a Philadelphia chromosome-positive lymphoid leukemia cell line using the CRISPR/Cas9 system
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Publisher
Singapore: Springer Nature Singapore
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Language
English
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Publisher
Singapore: Springer Nature Singapore
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Contents
Imatinib and second-generation tyrosine kinase inhibitors (TKIs) have dramatically improved the prognosis of Philadelphia chromosome-positive (Ph+) acute lymphoblastic leukemia (ALL). However, overcoming TKI resistance due to the T315I gatekeeper mutation of
BCR/ABL1
is crucial for further improving the prognosis. The clustered regularly inte...
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Full title
Introduction of the T315I gatekeeper mutation of BCR/ABL1 into a Philadelphia chromosome-positive lymphoid leukemia cell line using the CRISPR/Cas9 system
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TN_cdi_proquest_journals_2890038609
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_2890038609
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ISSN
0925-5710,1865-3774
E-ISSN
1865-3774
DOI
10.1007/s12185-022-03369-x
