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Androgen receptor signaling blockade enhances NK cell-mediated killing of prostate cancer cells and...

Androgen receptor signaling blockade enhances NK cell-mediated killing of prostate cancer cells and...

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_2891025557

Androgen receptor signaling blockade enhances NK cell-mediated killing of prostate cancer cells and sensitivity to NK cell checkpoint blockade

About this item

Full title

Androgen receptor signaling blockade enhances NK cell-mediated killing of prostate cancer cells and sensitivity to NK cell checkpoint blockade

Publisher

Cold Spring Harbor: Cold Spring Harbor Laboratory Press

Journal title

bioRxiv, 2023-11

Language

English

Formats

Publication information

Publisher

Cold Spring Harbor: Cold Spring Harbor Laboratory Press

More information

Scope and Contents

Contents

Background: The blockade of the androgen receptor (AR) pathway is an effective treatment for prostate cancer (PCa), but many patients progress to metastatic castration-resistant prostate cancer (mCRPC). Therapies for mCRPC include AR inhibitors (ARi), chemotherapy, PARP inhibitors, and radioligands. Checkpoint inhibitor activity is limited to a sma...

Alternative Titles

Full title

Androgen receptor signaling blockade enhances NK cell-mediated killing of prostate cancer cells and sensitivity to NK cell checkpoint blockade

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_proquest_journals_2891025557

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_2891025557

Other Identifiers

E-ISSN

2692-8205

DOI

10.1101/2023.11.15.567201