Conformational flexibility of HIV-1 envelope glycoproteins modulates transmitted / founder sensitivi...
Conformational flexibility of HIV-1 envelope glycoproteins modulates transmitted / founder sensitivity to broadly neutralizing antibodies
About this item
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Author / Creator
Parthasarathy, Durgadevi , Pothula, Karunakar Reddy , Dam, Kim-Marie A , Ratnapriya, Sneha , Benet, Héctor Cervera , Parsons, Ruth , Huang, Xiao , Sammour, Salam , Janowska, Katarzyna , Harris, Miranda , Sacco, Samuel , Sodroski, Joseph , Bridges, Michael D , Hubbell, Wayne L , Acharya, Priyamvada and Herschhorn, Alon
Publisher
United States: Cold Spring Harbor Laboratory Press
Journal title
Language
English
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Publication information
Publisher
United States: Cold Spring Harbor Laboratory Press
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Scope and Contents
Contents
HIV-1 envelope glycoproteins (Envs) mediate viral entry and are the sole target of neutralizing antibodies. Envs of most primary HIV-1 strains exist in a closed conformation and occasionally sample more open states. Thus, current knowledge guides immunogen design to mimic the closed Env conformation as the preferred target for eliciting broadly neu...
Alternative Titles
Full title
Conformational flexibility of HIV-1 envelope glycoproteins modulates transmitted / founder sensitivity to broadly neutralizing antibodies
Authors, Artists and Contributors
Author / Creator
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Record Identifier
TN_cdi_proquest_journals_2898140949
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_2898140949
Other Identifiers
ISSN
2692-8205
E-ISSN
2692-8205
DOI
10.1101/2023.09.13.557082
