SAM, SAH and C. elegans longevity: insights from a partial AHCY deficiency model
SAM, SAH and C. elegans longevity: insights from a partial AHCY deficiency model
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London: Nature Publishing Group
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English
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London: Nature Publishing Group
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Supplementation with S-adenosylhomocysteine (SAH) extends the lifespan of model organisms. To explore the impact of SAH on aging, we generated a Caenorhabditis elegans model by introducing the S-adenosylhomocysteine hydrolase (AHCY-1) variant Y145C, corresponding to the human AHCY Y143C pathogenic mutation. This mutation is anticipated to impair SA...
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SAM, SAH and C. elegans longevity: insights from a partial AHCY deficiency model
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TN_cdi_proquest_journals_2898163502
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_2898163502
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2056-3973
DOI
10.1038/s41514-023-00125-1
