Multifocal, multiphenotypic tumours arising from an MTOR mutation acquired in early embryogenesis
Multifocal, multiphenotypic tumours arising from an MTOR mutation acquired in early embryogenesis
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Author / Creator
Pacyna, Clarissa N , Anandapadamanaban, Madhanagopal , Loudon, Kevin W , Hay, Iain M , Perisic, Olga , Li, Ruoyan , Byrne, Matthew , Allen, Laura , Roberts, Kirsty , Hooks, Yvette , Warren, Anne Y , Stewart, Grant D , Clatworthy, Menna R , Teichmann, Sarah , Behjati, Sam , Campbell, Peter J , Williams, Roge L and Mitchell, Thomas J
Publisher
Cold Spring Harbor: Cold Spring Harbor Laboratory Press
Journal title
Language
English
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Publisher
Cold Spring Harbor: Cold Spring Harbor Laboratory Press
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Scope and Contents
Contents
Embryogenesis is a vulnerable time. Mutations in developmental cells can result in the wide dissemination of cells predisposed to disease within mature organs. We characterised the evolutionary history of four synchronous renal tumours from a 14-year-old girl, timing their shared origin to a multipotent embryonic cell committed to the right kidney,...
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Full title
Multifocal, multiphenotypic tumours arising from an MTOR mutation acquired in early embryogenesis
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Record Identifier
TN_cdi_proquest_journals_2901436834
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_2901436834
Other Identifiers
ISSN
2692-8205
E-ISSN
2692-8205
DOI
10.1101/2023.12.12.570785
