PA-594 CYP2C82 impacts desethylamodiaquine concentration upon repeated artesunate-amodiaquine treatm...
PA-594 CYP2C82 impacts desethylamodiaquine concentration upon repeated artesunate-amodiaquine treatment of uncomplicated malaria in Mali
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Author / Creator
Camara, Mahamadou Daby , Tekete, Mamadou , Dama, Souleyman , Sousa, Taís Nóbrega de , Kone, Aminatou , Toure Dinkorma, Ouelegouem Inna , Bamadio, Amadou , Djimde, Moussa , Dara, Antoine , Fofana, Bakary , Ogobara, Doumbo , Lauschke, Volker M , Borrmann, Steffen , Djimde, Abdoulaye A and Gil, José Pédro
Publisher
London: BMJ Publishing Group Ltd
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English
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Publisher
London: BMJ Publishing Group Ltd
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Contents
BackgroundCYP2C8 polymorphisms can impair the metabolism of the antimalarial amodiaquine and influence exposure to the key active metabolite desethylamodiaquine (DEAQ). CYP2C8*2 entailed to slow metabolism phenotype is the most frequent allele in Africa. Here we study the association between CYP2C8*2 carriage and DEAQ D7 drug level for repeated tre...
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Full title
PA-594 CYP2C82 impacts desethylamodiaquine concentration upon repeated artesunate-amodiaquine treatment of uncomplicated malaria in Mali
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TN_cdi_proquest_journals_2903075697
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_2903075697
Other Identifiers
E-ISSN
2059-7908
DOI
10.1136/bmjgh-2023-EDC.245
