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Branched-chain keto acids promote an immune-suppressive and neurodegenerative microenvironment in le...

Branched-chain keto acids promote an immune-suppressive and neurodegenerative microenvironment in le...

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_2903106428

Branched-chain keto acids promote an immune-suppressive and neurodegenerative microenvironment in leptomeningeal disease

About this item

Full title

Branched-chain keto acids promote an immune-suppressive and neurodegenerative microenvironment in leptomeningeal disease

Publisher

Cold Spring Harbor: Cold Spring Harbor Laboratory Press

Journal title

bioRxiv, 2023-12

Language

English

Formats

Publication information

Publisher

Cold Spring Harbor: Cold Spring Harbor Laboratory Press

More information

Scope and Contents

Contents

Leptomeningeal disease (LMD) occurs when tumors seed into the leptomeningeal space and cerebrospinal fluid (CSF), leading to severe neurological deterioration and poor survival outcomes. We utilized comprehensive multi-omics analyses of CSF from patients with lymphoma LMD to demonstrate an immunosuppressive cellular microenvironment and identified...

Alternative Titles

Full title

Branched-chain keto acids promote an immune-suppressive and neurodegenerative microenvironment in leptomeningeal disease

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_proquest_journals_2903106428

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_2903106428

Other Identifiers

E-ISSN

2692-8205

DOI

10.1101/2023.12.18.572239