Selective modulation of the androgen receptor AF2 domain rescues degeneration in spinal bulbar muscu...
Selective modulation of the androgen receptor AF2 domain rescues degeneration in spinal bulbar muscular atrophy
About this item
Full title
Author / Creator
Badders, Nisha M , Korff, Ane , Miranda, Helen C , Vuppala, Pradeep K , Smith, Rebecca B , Winborn, Brett J , Quemin, Emmanuelle R , Sopher, Bryce L , Dearman, Jennifer , Messing, James , Kim, Nam Chul , Moore, Jennifer , Freibaum, Brian D , Kanagaraj, Anderson P , Fan, Baochang , Tillman, Heather , Chen, Ping-Chung , Wang, Yingzhe , Freeman III, Burgess B. , Li, Yimei , Kim, Hong Joo , La Spada, Albert R and Taylor, J Paul
Publisher
New York: Springer New York
Journal title
Language
English
Formats
Publication information
Publisher
New York: Springer New York
Subjects
More information
Scope and Contents
Contents
A preclinical therapy to treat neurodegeneration is developed that selectively targets the AF-2 domain of the androgen receptor while sparing other functions of this receptor.
Spinal bulbar muscular atrophy (SBMA) is a motor neuron disease caused by toxic gain of function of the androgen receptor (AR). Previously, we found that co-regulator bind...
Alternative Titles
Full title
Selective modulation of the androgen receptor AF2 domain rescues degeneration in spinal bulbar muscular atrophy
Authors, Artists and Contributors
Author / Creator
Korff, Ane
Miranda, Helen C
Vuppala, Pradeep K
Smith, Rebecca B
Winborn, Brett J
Quemin, Emmanuelle R
Sopher, Bryce L
Dearman, Jennifer
Messing, James
Kim, Nam Chul
Moore, Jennifer
Freibaum, Brian D
Kanagaraj, Anderson P
Fan, Baochang
Tillman, Heather
Chen, Ping-Chung
Wang, Yingzhe
Freeman III, Burgess B.
Li, Yimei
Kim, Hong Joo
La Spada, Albert R
Taylor, J Paul
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_proquest_journals_2911667974
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_2911667974
Other Identifiers
ISSN
1078-8956
E-ISSN
1546-170X
DOI
10.1038/nm.4500
