ATP-Binding Free Energy Simulations Reveal an Allosteric Link Between the Enzyme Active Site and Mul...
ATP-Binding Free Energy Simulations Reveal an Allosteric Link Between the Enzyme Active Site and Multiple Functional Protein-Protein Interaction Interfaces in Cyclin Dependent Kinase-1
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Cold Spring Harbor: Cold Spring Harbor Laboratory Press
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English
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Cold Spring Harbor: Cold Spring Harbor Laboratory Press
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The ATP dependent phosphorylation activity of Cyclin Dependent Kinase 1 (CDK1), an essential enzyme for cell cycle progression, is intrinsically dependent upon interactions with Cyclin-B, substrate, and Cks proteins. A recent joint experimental-computational study from our group showed intriguingly that acetylation at the active site abrogated the...
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ATP-Binding Free Energy Simulations Reveal an Allosteric Link Between the Enzyme Active Site and Multiple Functional Protein-Protein Interaction Interfaces in Cyclin Dependent Kinase-1
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TN_cdi_proquest_journals_2914947458
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_2914947458
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2692-8205
DOI
10.1101/2024.01.15.575662
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https://www.proquest.com/docview/2914947458?pq-origsite=primo&accountid=13902
