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Decreased sarcomeric mitochondrial creatine kinase 2 impairs skeletal muscle mitochondrial function...

Decreased sarcomeric mitochondrial creatine kinase 2 impairs skeletal muscle mitochondrial function...

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_2914947688

Decreased sarcomeric mitochondrial creatine kinase 2 impairs skeletal muscle mitochondrial function independently of insulin action in type 2 diabetes

About this item

Full title

Decreased sarcomeric mitochondrial creatine kinase 2 impairs skeletal muscle mitochondrial function independently of insulin action in type 2 diabetes

Publisher

Cold Spring Harbor: Cold Spring Harbor Laboratory Press

Journal title

bioRxiv, 2024-01

Language

English

Formats

Publication information

Publisher

Cold Spring Harbor: Cold Spring Harbor Laboratory Press

More information

Scope and Contents

Contents

Plasma creatine levels are associated with risk of type 2 diabetes. Since skeletal muscle is the main disposal site of both creatine and glucose, we investigated the role of intramuscular creatine metabolism in the pathophysiology of insulin resistance in type 2 diabetes. We report in men with type 2 diabetes, plasma creatine levels are increased,...

Alternative Titles

Full title

Decreased sarcomeric mitochondrial creatine kinase 2 impairs skeletal muscle mitochondrial function independently of insulin action in type 2 diabetes

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_proquest_journals_2914947688

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_2914947688

Other Identifiers

ISSN

2692-8205

E-ISSN

2692-8205

DOI

10.1101/2024.01.11.575194