Dual-targeting CRISPR-CasRx reduces C9orf72 ALS/FTD sense and antisense repeat RNAs in vitro and in...
Dual-targeting CRISPR-CasRx reduces C9orf72 ALS/FTD sense and antisense repeat RNAs in vitro and in vivo
About this item
Full title
Author / Creator
Kempthorne, Liam , Vaizoglu, Deniz , Cammack, Alexander J , Carcole, Mireia , Suklai, Pacharaporn , Muralidharan, Bhavana , Kroll, Francois , Moens, Thomas G , Yshii, Lidia , Verschoren, Stijn , Holbling, Benedikt V , Katona, Eszter , Mikheenko, Alla , Coneys, Rachel , De Oliveira, Paula , Yong-Jie, Zhang , Jensen, Karen , Daughrity, Lillian M , Mcgown, Alexander , Ramesh, Tennore M , Van Den Bosch, Ludo , Rahim, Ahad A , Petrucelli, Leonard , Rihel, Jason and Isaacs, Adrian M
Publisher
Cold Spring Harbor: Cold Spring Harbor Laboratory Press
Journal title
Language
English
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Publication information
Publisher
Cold Spring Harbor: Cold Spring Harbor Laboratory Press
Subjects
More information
Scope and Contents
Contents
The most common genetic cause of both frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS) is a G4C2 repeat expansion in intron 1 of the C9orf72 gene. This repeat expansion undergoes bidirectional transcription to produce sense and antisense repeat RNA species. Both sense and antisense-derived repeat RNAs undergo repeat-associated...
Alternative Titles
Full title
Dual-targeting CRISPR-CasRx reduces C9orf72 ALS/FTD sense and antisense repeat RNAs in vitro and in vivo
Authors, Artists and Contributors
Author / Creator
Vaizoglu, Deniz
Cammack, Alexander J
Carcole, Mireia
Suklai, Pacharaporn
Muralidharan, Bhavana
Kroll, Francois
Moens, Thomas G
Yshii, Lidia
Verschoren, Stijn
Holbling, Benedikt V
Katona, Eszter
Mikheenko, Alla
Coneys, Rachel
De Oliveira, Paula
Yong-Jie, Zhang
Jensen, Karen
Daughrity, Lillian M
Mcgown, Alexander
Ramesh, Tennore M
Van Den Bosch, Ludo
Rahim, Ahad A
Petrucelli, Leonard
Rihel, Jason
Isaacs, Adrian M
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_proquest_journals_2919203822
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_2919203822
Other Identifiers
E-ISSN
2692-8205
DOI
10.1101/2024.01.26.577366
How to access this item
https://www.proquest.com/docview/2919203822?pq-origsite=primo&accountid=13902
