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Precision Enhancement of CAR-NK Cells through Non-Viral Engineering and Highly Multiplexed Base Edit...

Precision Enhancement of CAR-NK Cells through Non-Viral Engineering and Highly Multiplexed Base Edit...

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_2951255865

Precision Enhancement of CAR-NK Cells through Non-Viral Engineering and Highly Multiplexed Base Editing

About this item

Full title

Precision Enhancement of CAR-NK Cells through Non-Viral Engineering and Highly Multiplexed Base Editing

Publisher

United States: Cold Spring Harbor Laboratory Press

Journal title

bioRxiv, 2024-03

Language

English

Formats

Publication information

Publisher

United States: Cold Spring Harbor Laboratory Press

More information

Scope and Contents

Contents

Natural killer (NK) cells' unique ability to kill transformed cells expressing stress ligands or lacking major histocompatibility complexes (MHC) has prompted their development for immunotherapy. However, NK cells have demonstrated only moderate responses against cancer in clinical trials and likely require advanced genome engineering to reach thei...

Alternative Titles

Full title

Precision Enhancement of CAR-NK Cells through Non-Viral Engineering and Highly Multiplexed Base Editing

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_proquest_journals_2951255865

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_2951255865

Other Identifiers

ISSN

2692-8205

E-ISSN

2692-8205

DOI

10.1101/2024.03.05.582637