Optimization of amifostine administration for radioprotection
Optimization of amifostine administration for radioprotection
About this item
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Author / Creator
Publisher
ProQuest Dissertations & Theses
Date
2007
Language
English
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Publisher
ProQuest Dissertations & Theses
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Scope and Contents
Contents
Amifostine has been shown in randomized trials to protect the parotid gland, lung and esophagus from radiation. It is a thiophosphate prodrug that is dephosphorylated to the active free thiol metabolite, WR-1065, by plasma membrane-bound alkaline phosphatase. Selectivity of amifostine may be due to differences between the microenvironment of normal...
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Full title
Optimization of amifostine administration for radioprotection
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TN_cdi_proquest_journals_304845847
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_304845847
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ISBN
054930519X,9780549305194
