TLR8 agonist selgantolimod regulates Kupffer cell differentiation status and impairs HBV entry into...
TLR8 agonist selgantolimod regulates Kupffer cell differentiation status and impairs HBV entry into hepatocytes via an IL-6-dependent mechanism
About this item
Full title
Author / Creator
Roca Suarez, Armando Andres , Plissonnier, Marie-Laure , Grand, Xavier , Michelet, Maud , Giraud, Guillaume , Saez-Palma, Maria , Dubois, Anaëlle , Heintz, Sarah , Diederichs, Audrey , Van Renne, Nicolaas , Vanwolleghem, Thomas , Daffis, Stephane , Li, Li , Kolhatkar, Nikita , Hsu, Yao-Chun , Wallin, Jeffrey J , Lau, Audrey H , Fletcher, Simon P , Rivoire, Michel , Levrero, Massimo , Testoni, Barbara and Zoulim, Fabien
Publisher
England: BMJ Publishing Group Ltd and British Society of Gastroenterology
Journal title
Language
English
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Publication information
Publisher
England: BMJ Publishing Group Ltd and British Society of Gastroenterology
Subjects
More information
Scope and Contents
Contents
ObjectiveAchieving HBV cure will require novel combination therapies of direct-acting antivirals and immunomodulatory agents. In this context, the toll-like receptor 8 (TLR8) agonist selgantolimod (SLGN) has been investigated in preclinical models and clinical trials for chronic hepatitis B (CHB). However, little is known regarding its action on im...
Alternative Titles
Full title
TLR8 agonist selgantolimod regulates Kupffer cell differentiation status and impairs HBV entry into hepatocytes via an IL-6-dependent mechanism
Authors, Artists and Contributors
Author / Creator
Plissonnier, Marie-Laure
Grand, Xavier
Michelet, Maud
Giraud, Guillaume
Saez-Palma, Maria
Dubois, Anaëlle
Heintz, Sarah
Diederichs, Audrey
Van Renne, Nicolaas
Vanwolleghem, Thomas
Daffis, Stephane
Li, Li
Kolhatkar, Nikita
Hsu, Yao-Chun
Wallin, Jeffrey J
Lau, Audrey H
Fletcher, Simon P
Rivoire, Michel
Levrero, Massimo
Testoni, Barbara
Zoulim, Fabien
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_proquest_journals_3049862199
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_3049862199
Other Identifiers
ISSN
0017-5749,1468-3288
E-ISSN
1468-3288
DOI
10.1136/gutjnl-2023-331396
