ECM1 attenuates hepatic fibrosis by interfering with mediators of latent TGF-β1 activation
ECM1 attenuates hepatic fibrosis by interfering with mediators of latent TGF-β1 activation
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Author / Creator
Link, Frederik , Li, Yujia , Zhao, Jieling , Munker, Stefan , Fan, Weiguo , Nwosu, Zeribe C , Yao, Ye , Wang, Shanshan , Huang, Chenjun , Liebe, Roman , Hammad, Seddik , Liu, Hui , Shao, Chen , Gao, Chunfang , Sun, Bing , Török, Natalie J , Ding, Huiguo , Ebert, Matthias PA , Weng, Honglei , ten Dijke, Peter , Drasdo, Dirk , Dooley, Steven and Wang, Sai
Publisher
England: BMJ Publishing Group Ltd and British Society of Gastroenterology
Journal title
Language
English
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Publication information
Publisher
England: BMJ Publishing Group Ltd and British Society of Gastroenterology
Subjects
More information
Scope and Contents
Contents
ObjectiveExtracellular matrix protein 1 (ECM1) serves as a gatekeeper of hepatic fibrosis by maintaining transforming growth factor-β1 (TGF-β1) in its latent form. ECM1 knockout (KO) causes latent (L) TGF-β1 activation, resulting in hepatic fibrosis with rapid mortality. In chronic liver disease (CLD), ECM1 decreases with increasing CLD severity. W...
Alternative Titles
Full title
ECM1 attenuates hepatic fibrosis by interfering with mediators of latent TGF-β1 activation
Authors, Artists and Contributors
Author / Creator
Li, Yujia
Zhao, Jieling
Munker, Stefan
Fan, Weiguo
Nwosu, Zeribe C
Yao, Ye
Wang, Shanshan
Huang, Chenjun
Liebe, Roman
Hammad, Seddik
Liu, Hui
Shao, Chen
Gao, Chunfang
Sun, Bing
Török, Natalie J
Ding, Huiguo
Ebert, Matthias PA
Weng, Honglei
ten Dijke, Peter
Drasdo, Dirk
Dooley, Steven
Wang, Sai
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_proquest_journals_3120147461
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_3120147461
Other Identifiers
ISSN
0017-5749,1468-3288
E-ISSN
1468-3288
DOI
10.1136/gutjnl-2024-333213
