Solid-phase guanidyl-formation triggered peptide stapling and cyclization: A robust platform for imp...
Solid-phase guanidyl-formation triggered peptide stapling and cyclization: A robust platform for improving multiple properties of bioactive peptides
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Author / Creator
Wang, Nan , Chen, Baobao , Li, Xiang and Hu, Hong-Gang
Publisher
Washington: American Chemical Society
Journal title
Language
English
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Publisher
Washington: American Chemical Society
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Scope and Contents
Contents
Stapled or cyclic peptides offered advantageous membrane permeability and proteolytic stability to linear counterparts. We herein synthesized a series of S-alkyl-isothiourea building blocks, which could be conveniently coupled with one or two amine groups in both i,i+4 and i,i+7 space located within the peptides, enabling the silver-promoted solid-...
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Full title
Solid-phase guanidyl-formation triggered peptide stapling and cyclization: A robust platform for improving multiple properties of bioactive peptides
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TN_cdi_proquest_journals_3120650652
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_3120650652
Other Identifiers
E-ISSN
2573-2293
DOI
10.26434/chemrxiv-2024-gwdlq-v2
