Suppression of Huntington's Disease Somatic Instability by Transcriptional Repression and Direct CAG...
Suppression of Huntington's Disease Somatic Instability by Transcriptional Repression and Direct CAG Repeat Binding
About this item
Full title
Author / Creator
Mathews, Ella W , Coffey, Sydney R , Gärtner, Annette , Belgrad, Jillian , Bragg, Robert M , O'Reilly, Daniel , Cantle, Jeffrey P , McHugh, Cassandra , Summers, Ashley , Fentz, Joachim , Schwagarus, Tom , Cornelius, Antje , Lingos, Ioannis , Burch, Zoe , Kovalenko, Marina , Andrew, Marissa A , Frank Bennett, C , Kordasiewicz, Holly B , Marchionini, Deanna M , Wilkinson, Hilary , Vogt, Thomas F , Pinto, Ricardo M , Khvorova, Anastasia , Howland, David , Wheeler, Vanessa C and Carroll, Jeffrey B
Publisher
United States: Cold Spring Harbor Laboratory Press
Journal title
Language
English
Formats
Publication information
Publisher
United States: Cold Spring Harbor Laboratory Press
Subjects
More information
Scope and Contents
Contents
Huntington's disease (HD) arises from a CAG expansion in the
(
) gene beyond a critical threshold. A major thrust of current HD therapeutic development is lowering levels of mutant
mRNA (m
) and protein (mHTT) with the aim of reducing the toxicity of these product(s). Human genetic data also support a key role for somatic instability (S...
Alternative Titles
Full title
Suppression of Huntington's Disease Somatic Instability by Transcriptional Repression and Direct CAG Repeat Binding
Authors, Artists and Contributors
Author / Creator
Coffey, Sydney R
Gärtner, Annette
Belgrad, Jillian
Bragg, Robert M
O'Reilly, Daniel
Cantle, Jeffrey P
McHugh, Cassandra
Summers, Ashley
Fentz, Joachim
Schwagarus, Tom
Cornelius, Antje
Lingos, Ioannis
Burch, Zoe
Kovalenko, Marina
Andrew, Marissa A
Frank Bennett, C
Kordasiewicz, Holly B
Marchionini, Deanna M
Wilkinson, Hilary
Vogt, Thomas F
Pinto, Ricardo M
Khvorova, Anastasia
Howland, David
Wheeler, Vanessa C
Carroll, Jeffrey B
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_proquest_journals_3123918700
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_3123918700
Other Identifiers
ISSN
2692-8205
E-ISSN
2692-8205
DOI
10.1101/2024.11.04.619693
