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The AMD-associated genetic polymorphism CFH Y402H confers vulnerability to Hydroquinone-induced stre...

The AMD-associated genetic polymorphism CFH Y402H confers vulnerability to Hydroquinone-induced stre...

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_3125865166

The AMD-associated genetic polymorphism CFH Y402H confers vulnerability to Hydroquinone-induced stress in iPSC-RPE cells

About this item

Full title

The AMD-associated genetic polymorphism CFH Y402H confers vulnerability to Hydroquinone-induced stress in iPSC-RPE cells

Publisher

Cold Spring Harbor: Cold Spring Harbor Laboratory Press

Journal title

bioRxiv, 2024-11

Language

English

Formats

Publication information

Publisher

Cold Spring Harbor: Cold Spring Harbor Laboratory Press

More information

Scope and Contents

Contents

Age-related macular degeneration (AMD), a degenerative disease of the macula, is caused by an interplay of diverse risk factors (genetic predisposition, age and lifestyle habits). One of the main genetic risks includes the Y402H polymorphism in complement Factor H (FH), an inhibitor of complement system activation. There has been, and continues to...

Alternative Titles

Full title

The AMD-associated genetic polymorphism CFH Y402H confers vulnerability to Hydroquinone-induced stress in iPSC-RPE cells

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_proquest_journals_3125865166

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_3125865166

Other Identifiers

E-ISSN

2692-8205

DOI

10.1101/2024.11.06.622214