Harnessing micrometer-scale tPA beads for high plasmin flux and accelerated fibrinolysis
Harnessing micrometer-scale tPA beads for high plasmin flux and accelerated fibrinolysis
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Cold Spring Harbor: Cold Spring Harbor Laboratory Press
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English
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Cold Spring Harbor: Cold Spring Harbor Laboratory Press
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Rapid restoration of blood flow is critical in treating acute ischemic stroke. Current fibrinolytic therapies using tissue plasminogen activator (tPA) are limited by low recanalization rates and risks of off-target bleeding. Here, we present a strategy using tPA immobilized on micrometer-scale beads to enhance local plasmin generation. We synthesiz...
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Harnessing micrometer-scale tPA beads for high plasmin flux and accelerated fibrinolysis
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TN_cdi_proquest_journals_3126179718
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_3126179718
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DOI
10.1101/2024.11.06.621942
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https://www.proquest.com/docview/3126179718?pq-origsite=primo&accountid=13902
