Targeting GOF p53 and c-MYC through LZK Inhibition or Degradation Suppresses Head and Neck Tumor Gro...
Targeting GOF p53 and c-MYC through LZK Inhibition or Degradation Suppresses Head and Neck Tumor Growth
About this item
Full title
Author / Creator
Funk, Amy L , Katerji, Meghri , Afifi, Marwa , Nyswaner, Katherine , Woodroofe, Carolyn C , Edwards, Zoe C , Lindberg, Eric , Bergman, Knickole L , Gough, Nancy R , Rubin, Maxine R , Karpińska, Kamila , Trotter, Eleanor W , Dash, Sweta , Ries, Amy L , James, Amy , Robinson, Christina M , Difilippantonio, Simone , Karim, Baktiar O , Chang, Ting-Chia , Chen, Li , Xu, Xin , Doroshow, James H , Ahel, Ivan , Marusiak, Anna A , Swenson, Rolf E , Cappell, Steven D and Brognard, John
Publisher
United States: Cold Spring Harbor Laboratory Press
Journal title
Language
English
Formats
Publication information
Publisher
United States: Cold Spring Harbor Laboratory Press
Subjects
More information
Scope and Contents
Contents
The worldwide frequency of head and neck squamous cell carcinoma (HNSCC) is approximately 800,000 new cases, with 430,000 deaths annually. We determined that LZK (encoded by
) is a therapeutic target in HNSCC and showed that inhibition with small molecule inhibitors decreases the viability of HNSCC cells with amplified
. A drug-resistant muta...
Alternative Titles
Full title
Targeting GOF p53 and c-MYC through LZK Inhibition or Degradation Suppresses Head and Neck Tumor Growth
Authors, Artists and Contributors
Author / Creator
Katerji, Meghri
Afifi, Marwa
Nyswaner, Katherine
Woodroofe, Carolyn C
Edwards, Zoe C
Lindberg, Eric
Bergman, Knickole L
Gough, Nancy R
Rubin, Maxine R
Karpińska, Kamila
Trotter, Eleanor W
Dash, Sweta
Ries, Amy L
James, Amy
Robinson, Christina M
Difilippantonio, Simone
Karim, Baktiar O
Chang, Ting-Chia
Chen, Li
Xu, Xin
Doroshow, James H
Ahel, Ivan
Marusiak, Anna A
Swenson, Rolf E
Cappell, Steven D
Brognard, John
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_proquest_journals_3130983160
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_3130983160
Other Identifiers
ISSN
2692-8205
E-ISSN
2692-8205
DOI
10.1101/2024.11.19.623840
