Cardiovascular risk and obesity impact loss of grey matter volume earlier in males than females
Cardiovascular risk and obesity impact loss of grey matter volume earlier in males than females
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England: BMJ Publishing Group Ltd
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English
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England: BMJ Publishing Group Ltd
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BackgroundIt remains imperative to discover the time course that cardiovascular risk factors influence neurodegeneration in males and females and decipher whether the apolipoprotein (APOE) genotype mediates this relationship. Here we perform a large-scale evaluation of the influence of cardiovascular risk and obesity on brain volume in males and females in different age groups.Methods34 425 participants between the ages of 45 and 82 years were recruited from the UK Biobank database https://www.ukbiobank.ac.uk. T1-weighted structural MR images (n=34 425) were downloaded locally for all participants, and voxel-based morphometry was performed to characterise the volumetric changes of the whole brain. The influence of Framingham cardiovascular risk (general cardiovascular risk), abdominal subcutaneous adipose tissue, and visceral adipose tissue volume...
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Cardiovascular risk and obesity impact loss of grey matter volume earlier in males than females
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TN_cdi_proquest_journals_3147721499
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_3147721499
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ISSN
0022-3050,1468-330X
E-ISSN
1468-330X
DOI
10.1136/jnnp-2024-333675
